Pesquisa | Secretaria de Estado da Saúde

1.

T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.

Hirschhorn, Daniel; Budhu, Sadna; Kraehenbuehl, Lukas; Gigoux, Mathieu; Schröder, David; Chow, Andrew; Ricca, Jacob M; Gasmi, Billel; De Henau, Olivier; Mangarin, Levi Mark B; Li, Yanyun; Hamadene, Linda; Flamar, Anne-Laure; Choi, Hyejin; Cortez, Czrina A; Liu, Cailian; Holland, Aliya; Schad, Sara; Schulze, Isabell; Betof Warner, Allison; Hollmann, Travis J; Arora, Arshi; Panageas, Katherine S; Rizzuto, Gabrielle A; Duhen, Rebekka; Weinberg, Andrew D; Spencer, Christine N; Ng, David; He, Xue-Yan; Albrengues, Jean; Redmond, David; Egeblad, Mikala; Wolchok, Jedd D; Merghoub, Taha.

Cell ; 186(7): 1432-1447.e17, 2023 03 30.

Artigo Inglês | MEDLINE | ID: mdl-37001503

2.

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Lu, Sydney X; De Neef, Emma; Thomas, James D; Sabio, Erich; Rousseau, Benoit; Gigoux, Mathieu; Knorr, David A; Greenbaum, Benjamin; Elhanati, Yuval; Hogg, Simon J; Chow, Andrew; Ghosh, Arnab; Xie, Abigail; Zamarin, Dmitriy; Cui, Daniel; Erickson, Caroline; Singer, Michael; Cho, Hana; Wang, Eric; Lu, Bin; Durham, Benjamin H; Shah, Harshal; Chowell, Diego; Gabel, Austin M; Shen, Yudao; Liu, Jing; Jin, Jian; Rhodes, Matthew C; Taylor, Richard E; Molina, Henrik; Wolchok, Jedd D; Merghoub, Taha; Diaz, Luis A; Abdel-Wahab, Omar; Bradley, Robert K.

Cell ; 184(15): 4032-4047.e31, 2021 07 22.

Artigo Inglês | MEDLINE | ID: mdl-34171309

3.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Benci, Joseph L; Johnson, Lexus R; Choa, Ruth; Xu, Yuanming; Qiu, Jingya; Zhou, Zilu; Xu, Bihui; Ye, Darwin; Nathanson, Katherine L; June, Carl H; Wherry, E John; Zhang, Nancy R; Ishwaran, Hemant; Hellmann, Matthew D; Wolchok, Jedd D; Kambayashi, Taku; Minn, Andy J.

Cell ; 178(4): 933-948.e14, 2019 08 08.

Artigo Inglês | MEDLINE | ID: mdl-31398344

4.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla, Sachet A; Bachireddy, Pavan; Schilling, Bastian; Galonska, Christina; Zhan, Qian; Bango, Clyde; Langer, Rupert; Lee, Patrick C; Gusenleitner, Daniel; Keskin, Derin B; Babadi, Mehrtash; Mohammad, Arman; Gnirke, Andreas; Clement, Kendell; Cartun, Zachary J; Van Allen, Eliezer M; Miao, Diana; Huang, Ying; Snyder, Alexandra; Merghoub, Taha; Wolchok, Jedd D; Garraway, Levi A; Meissner, Alexander; Weber, Jeffrey S; Hacohen, Nir; Neuberg, Donna; Potts, Patrick R; Murphy, George F; Lian, Christine G; Schadendorf, Dirk; Hodi, F Stephen; Wu, Catherine J.

Cell ; 173(3): 624-633.e8, 2018 04 19.

Artigo Inglês | MEDLINE | ID: mdl-29656892

5.

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.

Wang, Haiping; Franco, Fabien; Tsui, Yao-Chen; Xie, Xin; Trefny, Marcel P; Zappasodi, Roberta; Mohmood, Syed Raza; Fernández-García, Juan; Tsai, Chin-Hsien; Schulze, Isabell; Picard, Florence; Meylan, Etienne; Silverstein, Roy; Goldberg, Ira; Fendt, Sarah-Maria; Wolchok, Jedd D; Merghoub, Taha; Jandus, Camilla; Zippelius, Alfred; Ho, Ping-Chih.

Nat Immunol ; 21(3): 298-308, 2020 03.

Artigo Inglês | MEDLINE | ID: mdl-32066953

6.

The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.

Chow, Andrew; Uddin, Fathema Z; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E; Quintanal-Villalonga, Alvaro; Chan, Joseph M; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A; Hellmann, Matthew D; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D; Merghoub, Taha; Rudin, Charles M.

Immunity ; 56(1): 93-106.e6, 2023 01 10.

Artigo Inglês | MEDLINE | ID: mdl-36574773

7.

Curbing Tregs' (Lack of) Enthusiasm.

Merghoub, Taha; Wolchok, Jedd D.

Cell ; 169(6): 981-982, 2017 06 01.

Artigo Inglês | MEDLINE | ID: mdl-28575677

8.

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Jiménez-Sánchez, Alejandro; Memon, Danish; Pourpe, Stephane; Veeraraghavan, Harini; Li, Yanyun; Vargas, Hebert Alberto; Gill, Michael B; Park, Kay J; Zivanovic, Oliver; Konner, Jason; Ricca, Jacob; Zamarin, Dmitriy; Walther, Tyler; Aghajanian, Carol; Wolchok, Jedd D; Sala, Evis; Merghoub, Taha; Snyder, Alexandra; Miller, Martin L.

Cell ; 170(5): 927-938.e20, 2017 Aug 24.

Artigo Inglês | MEDLINE | ID: mdl-28841418

9.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Xu, Shihao; Chaudhary, Omkar; Rodríguez-Morales, Patricia; Sun, Xiaoli; Chen, Dan; Zappasodi, Roberta; Xu, Ziyan; Pinto, Antonio F M; Williams, April; Schulze, Isabell; Farsakoglu, Yagmur; Varanasi, Siva Karthik; Low, Jun Siong; Tang, Wenxi; Wang, Haiping; McDonald, Bryan; Tripple, Victoria; Downes, Michael; Evans, Ronald M; Abumrad, Nada A; Merghoub, Taha; Wolchok, Jedd D; Shokhirev, Maxim N; Ho, Ping-Chih; Witztum, Joseph L; Emu, Brinda; Cui, Guoliang; Kaech, Susan M.

Immunity ; 54(7): 1561-1577.e7, 2021 07 13.

Artigo Inglês | MEDLINE | ID: mdl-34102100

10.

PD-1 Blockers.

Wolchok, Jedd D.

Cell ; 162(5): 937, 2015 Aug 27.

Artigo Inglês | MEDLINE | ID: mdl-26317459

11.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Chiappinelli, Katherine B; Strissel, Pamela L; Desrichard, Alexis; Li, Huili; Henke, Christine; Akman, Benjamin; Hein, Alexander; Rote, Neal S; Cope, Leslie M; Snyder, Alexandra; Makarov, Vladimir; Budhu, Sadna; Buhu, Sadna; Slamon, Dennis J; Wolchok, Jedd D; Pardoll, Drew M; Beckmann, Matthias W; Zahnow, Cynthia A; Merghoub, Taha; Mergoub, Taha; Chan, Timothy A; Baylin, Stephen B; Strick, Reiner.

Cell ; 162(5): 974-86, 2015 Aug 27.

Artigo Inglês | MEDLINE | ID: mdl-26317466

12.

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.

Rojas, Luis A; Sethna, Zachary; Soares, Kevin C; Olcese, Cristina; Pang, Nan; Patterson, Erin; Lihm, Jayon; Ceglia, Nicholas; Guasp, Pablo; Chu, Alexander; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Ruan, Jennifer; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Payne, George; Derhovanessian, Evelyna; Müller, Felicitas; Rhee, Ina; Yadav, Mahesh; Dobrin, Anton; Sadelain, Michel; Luksza, Marta; Cohen, Noah; Tang, Laura; Basturk, Olca; Gönen, Mithat; Katz, Seth; Do, Richard Kinh; Epstein, Andrew S; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M; Won, Elizabeth; Desai, Avni; Wei, Alice C; D'Angelica, Michael I; Kingham, T Peter; Mellman, Ira; Merghoub, Taha; Wolchok, Jedd D; Sahin, Ugur; Türeci, Özlem; Greenbaum, Benjamin D; Jarnagin, William R; Drebin, Jeffrey; O'Reilly, Eileen M.

Nature ; 618(7963): 144-150, 2023 Jun.

Artigo Inglês | MEDLINE | ID: mdl-37165196

13.

Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Hoyos, David; Zappasodi, Roberta; Schulze, Isabell; Sethna, Zachary; de Andrade, Kelvin César; Bajorin, Dean F; Bandlamudi, Chaitanya; Callahan, Margaret K; Funt, Samuel A; Hadrup, Sine R; Holm, Jeppe S; Rosenberg, Jonathan E; Shah, Sohrab P; Vázquez-García, Ignacio; Weigelt, Britta; Wu, Michelle; Zamarin, Dmitriy; Campitelli, Laura F; Osborne, Edward J; Klinger, Mark; Robins, Harlan S; Khincha, Payal P; Savage, Sharon A; Balachandran, Vinod P; Wolchok, Jedd D; Hellmann, Matthew D; Merghoub, Taha; Levine, Arnold J; Luksza, Marta; Greenbaum, Benjamin D.

Nature ; 606(7912): 172-179, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35545680

14.

Anatomic position determines oncogenic specificity in melanoma.

Weiss, Joshua M; Hunter, Miranda V; Cruz, Nelly M; Baggiolini, Arianna; Tagore, Mohita; Ma, Yilun; Misale, Sandra; Marasco, Michelangelo; Simon-Vermot, Theresa; Campbell, Nathaniel R; Newell, Felicity; Wilmott, James S; Johansson, Peter A; Thompson, John F; Long, Georgina V; Pearson, John V; Mann, Graham J; Scolyer, Richard A; Waddell, Nicola; Montal, Emily D; Huang, Ting-Hsiang; Jonsson, Philip; Donoghue, Mark T A; Harris, Christopher C; Taylor, Barry S; Xu, Tianhao; Chaligné, Ronan; Shliaha, Pavel V; Hendrickson, Ronald; Jungbluth, Achim A; Lezcano, Cecilia; Koche, Richard; Studer, Lorenz; Ariyan, Charlotte E; Solit, David B; Wolchok, Jedd D; Merghoub, Taha; Rosen, Neal; Hayward, Nicholas K; White, Richard M.

Nature ; 604(7905): 354-361, 2022 04.

Artigo Inglês | MEDLINE | ID: mdl-35355015

15.

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c⁺CD103⁺ Monocytic Antigen-Presenting Cells in Tumors.

Sharma, Madhav D; Rodriguez, Paulo C; Koehn, Brent H; Baban, Babak; Cui, Yan; Guo, Gang; Shimoda, Michiko; Pacholczyk, Rafal; Shi, Huidong; Lee, Eun-Joon; Xu, Hongyan; Johnson, Theodore S; He, Yukai; Mergoub, Taha; Venable, Christopher; Bronte, Vincenzo; Wolchok, Jedd D; Blazar, Bruce R; Munn, David H.

Immunity ; 48(1): 91-106.e6, 2018 01 16.

Artigo Inglês | MEDLINE | ID: mdl-29343444

16.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Chiappinelli, Katherine B; Strissel, Pamela L; Desrichard, Alexis; Li, Huili; Henke, Christine; Akman, Benjamin; Hein, Alexander; Rote, Neal S; Cope, Leslie M; Snyder, Alexandra; Makarov, Vladimir; Budhu, Sadna; Slamon, Dennis J; Wolchok, Jedd D; Pardoll, Drew M; Beckmann, Matthias W; Zahnow, Cynthia A; Merghoub, Taha; Chan, Timothy A; Baylin, Stephen B; Strick, Reiner.

Cell ; 169(2): 361, 2017 04 06.

Artigo Inglês | MEDLINE | ID: mdl-28388418

17.

CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.

Zappasodi, Roberta; Serganova, Inna; Cohen, Ivan J; Maeda, Masatomo; Shindo, Masahiro; Senbabaoglu, Yasin; Watson, McLane J; Leftin, Avigdor; Maniyar, Rachana; Verma, Svena; Lubin, Matthew; Ko, Myat; Mane, Mayuresh M; Zhong, Hong; Liu, Cailian; Ghosh, Arnab; Abu-Akeel, Mohsen; Ackerstaff, Ellen; Koutcher, Jason A; Ho, Ping-Chih; Delgoffe, Greg M; Blasberg, Ronald; Wolchok, Jedd D; Merghoub, Taha.

Nature ; 591(7851): 652-658, 2021 03.

Artigo Inglês | MEDLINE | ID: mdl-33588426

18.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Chiappinelli, Katherine B; Strissel, Pamela L; Desrichard, Alexis; Li, Huili; Henke, Christine; Akman, Benjamin; Hein, Alexander; Rote, Neal S; Cope, Leslie M; Snyder, Alexandra; Makarov, Vladimir; Budhu, Sadna; Slamon, Dennis J; Wolchok, Jedd D; Pardoll, Drew M; Beckmann, Matthias W; Zahnow, Cynthia A; Merghoub, Taha; Chan, Timothy A; Baylin, Stephen B; Strick, Reiner.

Cell ; 164(5): 1073, 2016 Feb 25.

Artigo Inglês | MEDLINE | ID: mdl-27064190

19.

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.

Moral, John Alec; Leung, Joanne; Rojas, Luis A; Ruan, Jennifer; Zhao, Julia; Sethna, Zachary; Ramnarain, Anita; Gasmi, Billel; Gururajan, Murali; Redmond, David; Askan, Gokce; Bhanot, Umesh; Elyada, Ela; Park, Youngkyu; Tuveson, David A; Gönen, Mithat; Leach, Steven D; Wolchok, Jedd D; DeMatteo, Ronald P; Merghoub, Taha; Balachandran, Vinod P.

Nature ; 579(7797): 130-135, 2020 03.

Artigo Inglês | MEDLINE | ID: mdl-32076273

20.

Targeting T Cell Co-receptors for Cancer Therapy.

Callahan, Margaret K; Postow, Michael A; Wolchok, Jedd D.

Immunity ; 44(5): 1069-78, 2016 05 17.

Artigo Inglês | MEDLINE | ID: mdl-27192570

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.

The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.

Curbing Tregs' (Lack of) Enthusiasm.

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

PD-1 Blockers.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.

Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Anatomic position determines oncogenic specificity in melanoma.

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c⁺CD103⁺ Monocytic Antigen-Presenting Cells in Tumors.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.

Targeting T Cell Co-receptors for Cancer Therapy.